Correlation of Hcy,hs-CRP and testosterone levels with risk of cerebral atherosclerosis in elderly males
10.3969/j.issn.1009-0126.2025.10.017
- VernacularTitle:同型半胱氨酸和高敏C反应蛋白及睾酮水平与老年男性脑动脉硬化患者的相关性分析
- Author:
Xiaolin ZHANG
1
;
Lihua QIAN
1
;
Xuebo PANG
1
;
Meirong WANG
1
;
Yongmei KONG
1
Author Information
1. 054000 邢台市中心医院神经内科
- Publication Type:Journal Article
- Keywords:
intracranial arteriosclerosis;
homocysteine;
C-reactive protein;
testosterone
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(10):1363-1366
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations between homocysteine(Hcy),high sensitivity C-reactive protein(hs-CRP)and testosterone levels and elderly male cerebral atherosclerosis(AS).Methods A total of 118 elderly male patients with cerebral AS admitted to our department from May 2020 to May 2022 were recruited and served as AS group.The group were further divided into an unstable plaque subgroup(37 cases)and a stable plaque subgroup(81 cases)ac-cording to the plaque property.Another 118 healthy elderly males who taking health checkup in our hospital during the same period were subjected and served as the non-AS group.The levels of serum Hcy,hs-CRP and testosterone were measured in all participants.The relationship between Hcy,hs-CRP and testosterone levels and cerebral AS was analyzed.Results The AS group had significantly larger proportion of hyperlipidemia and higher levels of Hcy and hs-CRP,but lower testosterone level when compared with the non-AS group(P＜0.01).Multivariate logistic regres-sion analysis identified hyperlipidemia(OR=4.651,95％CI:1.790-12.080,P=0.002),Hcy(OR=1.592,95％CI:1.112-2.279,P=0.011)and hs-CRP(OR=2.951,95％CI:1.412-6.165,P=0.004)were risk factors,while testosterone was a protective factor(OR=0.661,95％CI:0.450-0.971,P=0.035)for occurrence of cerebral AS in elderly males.The levels of Hcy and hs-CRP were notably higher,and that of testosterone was remarkably lower in the unstable plaque subgroup than the stable plaque subgroup(P＜0.05,P＜0.01).ROC curve analysis indicated that the AUC value of Hcy,hs-CRP and testosterone in evaluating plaque stability in elderly male patients with cerebral AS was 0.806,0.795 and 0.712,respectively.Conclusion The abnormal lev-els of Hcy,hs-CRP and testosterone are related to the risk of cerebral AS in elderly males,and their levels have certain predictive value in predicting the plaque stability.
