Carotid ultrasound combined with TNF-α and receptor-interacting protein kinase 1 in evaluating prognosis of acute ischemic stroke
10.3969/j.issn.1009-0126.2025.10.022
- VernacularTitle:颈动脉超声联合肿瘤坏死因子α和受体相互作用蛋白激酶1评估急性缺血性脑卒中预后分析
- Author:
Hao JIANG
1
;
Milin WEI
1
;
Yingna SHI
1
Author Information
1. 232052 淮南新华医疗集团新华医院超声医学科
- Publication Type:Journal Article
- Keywords:
stroke;
carotid arteries;
ultrasonography,doppler;
tumor necrosis factor-alpha;
prognosis
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(10):1386-1389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prognostic value of carotid ultrasound quantitative parameters combined with serum TNF-α and receptor-interacting protein kinase 1(RIPK1)levels for patients with acute ischemic stroke(AIS).Methods A total of 110 AIS patients admitted in our hospital from February 2020 to May 2024 were enrolled,and according to their modified Rankin scale(mRS)score after 3 months,they were divided into a good prognosis group(76 cases)and a poor prognosis group(34 cases).The carotid ultrasound quantitative parameters such as intima-media thickness(CIMT),end diastolic velocity(EDV)and peak systolic velocity(PSV)and serum TNF-α and RIPK1 levels were detected.The relationship of the parameters and the serum levels with prognosis was analyzed.Results The poor prognosis group had significantly higher carotid CIMT and EDV values and serum levels of TNF-α and RIPK1,and lower PSV value than the good prognosis group(P＜0.01).The CIMT,PSV,EDV,TNF-α and RIPK1 were independent in-fluencing factors of prognosis of AIS patients(P＜0.01).ROC curve analysis showed that the AUC value of CIMT,PSV,EDV,TNF-α and RIPK1 combined together in predicting the poor prognosis of AIS patients was 0.979,with a sensitivity of 94.10％and a specificity of 75.00％.Conclusion Carotid ultrasound quantitative parameters combined with serum TNF-α and RIPK1 levels can effectively assess the prognosis of AIS patients,with high predictive value.
