The efficacy of Ludangshen oral liquid combined with piperacillin tazobactam in the treatment of severe pneumonia and its influence on inflammatory factors and immune function
10.3969/j.issn.1673-9701.2025.28.012
- VernacularTitle:潞党参口服液联合哌拉西林他唑巴坦治疗重症肺炎的疗效及其对炎症因子和免疫功能的影响
- Author:
Yukun ZHANG
1
;
Zilin LIU
;
Jian HUANG
Author Information
1. 江西省胸科医院ICU,江西南昌 330006
- Publication Type:Journal Article
- Keywords:
Severe pneumonia;
Ludangshen oral liquid;
Piperacillin tazobactam;
Clinical efficacy;
Safety
- From:
China Modern Doctor
2025;63(28):53-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of Ludangshen oral liquid combined with piperacillin tazobactam in the treatment of severe pneumonia and its influence on inflammatory factors and immune function.Methods A total of 80 patients with severe pneumonia who were treated in Jiangxi Chest Hospital from January 2024 to March 2025 were selected and randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with intravenous infusion of piperacillin tazobactam,while the observation group was additionally given Ludangshen oral liquid on the basis of the treatment given to control group.The therapeutic effects,inflammatory indicators[interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP)],immune function indicators[immunoglobulin(Ig)G,IgA,IgM],blood gas indicators[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),pH,fraction of inspired oxygen(FiO2)],pulmonary function indicators[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC]and the occurrence of drug-related adverse events of two groups of patients were compared.Results The total effective rate of treatment in observation group was significantly higher than that in control group(P＜0.05).After treatment,IL-6,PCT,CRP,PaCO2 and FiO2 in both groups of patients were significantly lower than those before treatment,while IgG,IgA,IgM,PaO2,pH,FEV1,FVC and FEV1/FVC were significantly higher than those before treatment(P＜0.05).The IL-6,PCT,CRP,PaCO2 and FiO2 in observation group were significantly lower than those in control group,while IgG,IgA,IgM,PaO2,pH,FEV1,FVC and FEV1/FVC were significantly higher than those in control group(P＜0.05).During the treatment period,there was no statistically significant difference in the incidence of drug-related adverse events between two groups of patients(P＞0.05).Conclusion The combination of Ludangshen oral liquid and piperacillin tazobactam for the treatment of severe pneumonia has a good efficacy,can enhance pulmonary function,and has a good safety.
