Use of analgesic drugs and the incidence of Clostridium difficile enteritis:Mendelian randomized study
10.3969/j.issn.1673-9701.2025.28.005
- VernacularTitle:镇痛药物使用与艰难梭菌性肠炎:孟德尔随机化研究
- Author:
Renli WANG
1
;
Rongjun LIU
;
Hua WANG
;
Zhaojun XU
Author Information
1. 宁波市第二医院重症医学科,浙江宁波 315010
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
Analgesic drugs;
Clostridium difficile enteritis
- From:
China Modern Doctor
2025;63(28):17-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the causal relationship between use of analgesic drugs and incidence of Clostridium difficile enteritis(CDE).Methods Univariate and multivariate Mendelian randomization(MR)methods were employed to investigate the potential causal relationship between use of analgesic drugs and incidence of CDE,using inverse variance weighted as the primary analytical approach.Results Univariate MR analysis indicated that use of nonsteroidal anti-inflammatory drug(NSAID)(OR=2.680,95％CI:1.689-4.252,P＜0.001)and aniline derivatives(OR=2.521,95％CI:1.503-4.229,P＜0.001)increased the risk of CDE,whereas use of opioids(OR=0.955,95％CI:0.818-1.114,P=0.556)and salicylates(OR=1.081,95％CI:0.820-1.425,P=0.579)were not identified as risk factors for CDE.The MR-Steiger test did not suggest the presence of reverse causality between exposure and outcome.After adjustment in the multivariate MR analysis,the use of NSAID was no longer a risk factor for CDE(OR=1.709,95％CI:0.864-3.308,P=0.123),while use of aniline derivatives remained a risk factor(OR=2.147,95％CI:1.239-3.721,P=0.003).Sensitivity analyses showed no evidence of heterogeneity,horizontal pleiotropy,or outliers,and no single nucleotide polymorphisms independently influenced the results.Conclusion The use of opioids does not increase the risk of CDE infection.The causal relationship between NSAID use and CDE remains inconclusive.However,the use of aniline derivatives within the NSAID class is a risk factor for CDE,while use of salicylates is not a risk factor for CDE.
