Analysis of hepatitis C infection status in a general grade III hospital in Beijing
10.3760/cma.j.cn112866-20250120-00013
- VernacularTitle:北京市某综合三甲医院就诊患者中丙型肝炎感染筛查现状分析
- Author:
Haiying ZHANG
1
;
Runling ZHANG
1
;
Yuyuan JIA
1
;
Yan LIU
1
;
Zhenyu WANG
1
;
Ling ZHU
1
;
Hongsong CHEN
1
;
Huiying RAO
1
Author Information
1. 北京大学人民医院 北京大学肝病研究所 北京大学人民医院感染与肝病中心 丙型肝炎和肝病免疫治疗北京市重点实验室 非酒精性脂肪性肝病诊断北京市国际科技合作基地，北京 100044
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus;
Hepatitis C antibody infection status;
Nucleic acid detection rate;
Nucleic acid positive rate;
Clear policy
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(2):219-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the prevalence of hepatitis C virus (HCV) infection among patients attending a comprehensive tertiary hospital in Beijing and to pinpoint the key demographics for anti-HCV screening.Methods:A comprehensive retrospective analysis was undertaken, examining data from 631 424 patients who underwent anti-HCV testing between 2017 and 2023. Testing for anti-HCV was conducted using the Abbott i2000 fully automated chemiluminescent immunoassay analyzer. HCV nucleic acid testing was performed with the Roche Cobas AmpliPrep/Cobas TaqMan 96 fluorescent quantitative PCR system, while HCV genotyping was achieved through sequencing.Results:The positive rate of HCV antibodies demonstrated a gradual decline over the years, decreasing from 1.62% in 2017 to 1.01% in 2023. The overall positive rate stood at 1.36% (8 574/631 424), with a nucleic acid testing rate of 59.24% (5 079/8 574) and a nucleic acid positive rate of 34.28% (1 741/5 079). The majority of anti-HCV positive patients came from the department of hepatology (12.17%), followed by hepatobiliary surgery (3.03%), emergency medicine (1.68%), cardiovascular medicine (1.24%) and ophthalmology clinic (1.23%). Notably, the anti-HCV positive rate was significantly elevated in the ≥40 years old group compared to the <40 years old group, with statistical significance ( χ2=1 892.577, P=0.000). The highest anti-HCV positive rates were observed within the 60-69- and 80-99-years old brackets (both at 1.85%), while the peak HCV RNA positive rate was recorded in the 50-59 years old group (27.08%). Females exhibited a significantly higher positive rate (18.53%) than males (15.75%) ( χ2=8.066, P<0.01). When anti-HCV levels surpassed 9 S/CO, the HCV RNA positive rate was notably high, exceeding 38.97%. Intriguingly, at antibody levels ranging from 15 to 16 S/CO, the HCV RNA positive rate climbed to a maximum of 56.17%. Conclusions:This study has successfully identified the key populations for anti-HCV screening: Patients aged over 40, particularly female patients within the 50-69 age bracket; Patients in hepatology, hepatobiliary surgery, emergency medicine, cardiovascular medicine and ophthalmology departments.
