Analysis of human bocavirus characteristics in children with acute respiratory infections in Bengbu City, Anhui province, 2024
10.3760/cma.j.cn112866-20250318-00063
- VernacularTitle:2024年安徽省蚌埠市急性呼吸道感染儿童中人博卡病毒的感染流行特征分析
- Author:
Xinyue CHEN
1
;
Yingli QU
;
Jin CAO
;
Wenyan TIAN
;
Guangyu XUE
;
Yuting HU
;
Qin LUO
;
Qinqin SONG
;
Haijun DU
;
Guoyong MEI
;
Zhiqiang XIA
;
Juan SONG
;
Jun HAN
;
Guoyu LU
Author Information
1. 蚌埠医学院第一附属医院，蚌埠 23300
- Publication Type:Journal Article
- Keywords:
Acute respiratory infection;
Human bocavirus;
Epidemiological characteristics;
Genotyping
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(2):214-218
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the epidemiological characteristics of human bocavirus (HBoV) in children with acute respiratory infections (ARI) in Bengbu City, Anhui Province, in 2024.Methods:Nasopharyngeal swab samples were collected from 269 children with ARI in Bengbu City, Anhui Province, in 2024. Seventeen respiratory pathogens were screened using quantitative fluorescence PCR. For HBoV-positive samples, the VP1/VP2 structural gene fragments of HBoV were amplified and sequenced for genetic evolutionary analysis.Results:Among the 269 nasopharyngeal swab samples from children with ARI, the overall detection rate of respiratory pathogens was 48.33% (103/269). The top three pathogens with the highest detection rates were: Influenza A virus (FluA): 10.04% (27/269), Respiratory syncytial virus (RSV): 8.18% (22/269), Human bocavirus (HBoV): 7.43% (20/269). The age distribution of HBoV-infected children showed that the detection rate was highest in the 0-2 years age group (50%, 10/20), followed by the 3-5 years age group (25%, 5/20) and the over 6 years age group (25%, 5/20). However, there was no statistically significant difference in viral detection rates among the age groups. Genetic evolutionary analysis based on VP1/VP2 revealed that all 13 HBoV strains were of the HBoV-1 genotype.Conclusions:HBoV is one of the major pathogens causing ARI in children in Bengbu City, Anhui Province, in 2024, with HBoV-1 being the predominant genotype. Additionally, infants aged 0-2 years are the most susceptible population to HBoV infection.
