Clinical characteristics and risk factors of human cytomegalovirus infection in pediatric patients after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.cn112866-20250430-00089
- VernacularTitle:儿童异基因造血干细胞移植术后人巨细胞病毒感染的临床特征及危险因素分析
- Author:
Yuting HU
1
;
Guangyu XUE
;
Shunqiao FENG
;
Qin LUO
;
Yingli QU
;
Jin CAO
;
Wenyan TIAN
;
Feng HE
;
Haijun DU
;
Chen GAO
;
Qinqin SONG
;
Hailan YAO
;
Jun HAN
Author Information
1. 内蒙古科技大学包头医学院公共卫生学院，包头 014040
- Publication Type:Journal Article
- Keywords:
allo-hematopoietic stem cell transplantation;
Human cytomegalovirus;
Clinical characteristics;
Risk factors;
Relapse
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(3):345-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the risk factors for human cytomegalovirus (HCMV) infection in pediatric recipients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods:Clinical data of children who underwent first allo-HSCT were retrospectively analyzed from March 2017 to November 2024. A total of 259 pediatric allo-HSCT recipients were analyzed through comparing HCMV infection group (n=115) and Non-HCMV infection group (n=144). Clinical characteristics were compared, and risk factors for HCMV infection were analyzed using univariate and multivariate logistic regression.Results:The result of univariate analysis showed that adrenoleukodystrophy (ALD), length of hospitalization, duration of antiviral therapy, and bacterial infection were significantly associated with HCMV infection in pediatric allo-HSCT recipients ( P<0.05). The result of multivariate analysis showed that ALD was an independent protective factor against HCMV infection of allo-HSCT recipients ( P<0.05) [OR=0.22, 95% CI: 0.06-0.86], while umbilical cord blood transplantation (UCBT) was an independent risk factor for HCMV infection in allo-HSCT recipients ( P<0.05) [OR=6.13, 95% CI: 1.34-28.04]. When the area under the ROC curve (AUC) for predicting post-transplant relapse based on HCMV viral load was 0.75 (95% CI: 0.55-0.94, P=0.014) and at the cutoff value of 3×10 3 copies/ml, the sensitivity and specificity for predicting relapse were 81.13% and 66.67%, respectively. Conclusions:HCMV infection in pediatric allo-HSCT recipients may lead to longer hospitalization and increased risk of relapse.
