Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China
10.3760/cma.j.cn112150-20240625-00500
- VernacularTitle:中国部分地区40~89岁中老年人尿镉水平与甲状腺激素水平的关联研究
- Author:
Changzi WU
1
;
Xiaochen WANG
;
Yue CHEN
;
Zheng LI
;
Yi ZHANG
;
Yuan WEI
;
Bing WU
;
Wenli ZHANG
;
Zhengxiong YANG
;
Xiaojie DONG
;
Ruiting HAO
;
Xiu YE
;
Luxi WEI
;
Yingli QU
;
Haiyan CHU
;
Yuebin LYU
;
Ying ZHU
;
Dongqun XU
;
Xiaoming SHI
Author Information
1. 南京医科大学公共卫生学院全球健康中心，南京 211166
- Publication Type:Journal Article
- Keywords:
Cadmium;
Thyroid hormone;
Cross-sectional studies;
Middle-aged and older adults
- From:
Chinese Journal of Preventive Medicine
2025;59(2):209-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between urinary cadmium levels and thyroid hormone levels in people aged 40-89 years old in selected areas of China.Methods:Based on the "Investigation of the Impact of Soil Quality of Agricultural Land on Human Health in Typical Areas" project from October 2019 to August 2020, a multi-stage stratified random sampling method was used to include 6 588 middle-aged and older adults aged 40-89. Demographic characteristics, dietary frequency and disease status were collected through the questionnaire and physical examination. Urinary cadmium and urinary creatinine were detected by random midstream urine. Fasting venous blood was collected for the detection of Triiodothyronine (T3) and Thyroxine (T4). The linear mixed effects model was used to explore the association of urine cadmium levels with thyroid hormone levels. Its dose-response relationship was explored by using the restricted cubic spline.Results:The age of the subjects was (63.48±12.18) years, with males accounting for 51.28%. The M ( Q 1,Q 3) of urinary cadmium level, T3 and T4 was 2.48 (1.36, 4.42) μg/g·creatinine, (1.96±0.51) nmol/L and (113.75±29.11) nmol/L, respectively. The linear mixed effects model showed that the changes of T3 and T4 were 0.027 (0.009, 0.044) nmol/L and 2.019 (1.084, 2.953) nmol/L for each one-unit increase (natural logarithm transformed) of urinary cadmium. The restricted cubic spline showed that there was a positive nonlinear association between urinary cadmium and T3 as well as T4 (all Pnonlinear<0.05). Conclusion:In selected areas of China, the urinary cadmium level of middle-aged and older adults aged 40-89 years is positively associated with T3 and T4.
