Analysis of circRNAs expression in peripheral blood of residents around radon hot springs
10.3760/cma.j.cn112271-20240628-00244
- VernacularTitle:氡温泉周围居民外周血circRNAs表达分析
- Author:
Jia ZHANG
1
;
Jianlei RUAN
1
;
Xiaoliang LI
1
;
Jianxiang LIU
1
Author Information
1. 中国疾病预防控制中心辐射防护与核安全医学所 辐射防护与核应急中国疾病预防控制中心重点实验室，北京 100088
- Publication Type:Journal Article
- Keywords:
Radon hot spring;
Peripheral blood;
circRNAs;
Cumulative doses
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(3):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of circular RNAs (circRNAs) expressions in peripheral blood of residents around radon hot springs.Methods:Totally 51 residents around radon hot springs were selected as the radon hot sping group, and another 51 residents around non-radon hot springs were selected as the control group. Questionnaires were used to collect demographic information and the radon exposure levels in the two groups. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative expressions of selected circRNA candidates in peripheral blood of the two groups. Mann-Whitney U test was used to compare the differences in the relative expressions of the circRNAs between the two groups. Results:The cumulative doses of radon exposure per capita for residents around radon hot springs was (111.47±99.03) mSv, with dose range 3.32-458.68 mSv. The difference in the relative expressions of hsa_circ_0040573 between the two groups was statistically significant ( Z=-2.88, P<0.05). The expression of hsa_circ_0040573 was suppressed by radon exposure ( t=-2.52, P<0.05) with a dose-dependent manner ( H=12.21, P<0.05). Conclusion:Hsa_circ_0040573 has a potential to serve as a radiological response biomarker for radon exposure, contributing to early diagnosis and monitoring of health risks associated with radon exposure.
