Successful immunization of large-scale horses with live attenuated vaccine against Japanese encephalitis
10.3760/cma.j.cn112866-20250214-00032
- VernacularTitle:流行性乙型脑炎减毒活疫苗大规模免疫马获得成功
- Author:
Guodong LIANG
1
Author Information
1. 中国疾病预防控制中心病毒病预防控制所 传染病溯源预警与智能决策全国重点实验室，北京 102206
- Publication Type:Journal Article
- Keywords:
Japanese encephalitis virus (JEV);
Live attenuated vaccine for Japanese encephalitis;
SA14-14-2 Strain;
SA14-2-8 Strain.
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(3):265-269
- CountryChina
- Language:Chinese
-
Abstract:
Chinese scientists have successfully developed two live attenuated vaccines for Japanese encephalitis (JE) using the SA14 strain of the Japanese encephalitis virus as the parent virus: the SA14-14-2 strain and the SA14-2-8 strain. The former has been widely publicized for its successful use in preventing and controlling JE in humans, while the latter′s success in immunizing hundreds of thousands of horses is less well-known. The successful result of large-scale immunization of large mammals with the SA14-2-8 attenuated strain provide scientific data for the use of live attenuated vaccines for JE in humans, which is of significant importance. This paper introduces the attenuation process of the SA14-2-8 strain and its large-scale immunization in horses, in commemoration of the contributions made by the older generation of virologists to the study of virology and vaccinology in China. It also offers insights into the technical routes for developing live attenuated vaccines for arboviruses, as the attenuation pathway and technical route of the SA14-2-8 strain differ completely from those of SA14-14-2.
