Significance of enteric nervous system disorders in Crohn's disease
10.3760/cma.j.cn101480-20240416-00047
- VernacularTitle:肠道神经系统紊乱在克罗恩病中的意义
- Author:
Xue DENG
1
;
Lingling YANG
;
Yue ZHANG
;
Hong GUO
;
Wei WANG
;
Xuefeng TANG
Author Information
1. 重庆医科大学，重庆 400016
- Publication Type:Journal Article
- Keywords:
Crohn 's disease;
Enteric nervous system;
Pathophysiological mechanism;
Histological manifestations;
Plexitis;
Recurrence
- From:
Chinese Journal of Inflammatory Bowel Diseases
2025;09(2):158-163
- CountryChina
- Language:Chinese
-
Abstract:
Crohn 's disease (CD) is an intestinal inflammatory disease of unknown etiology, the pathophysiological mechanism is still unclear. The enteric nervous system (ENS) is responsible for the autonomous regulation of intestinal function. Therefore, ENS dysfunction may be the core of the pathophysiological mechanism of CD. Here, we review the pathophysiological mechanism by which ENS contributes to the development of CD, with a focus on the role of aberrant histological manifestations of ENS and plexitis in predicting the recurrence of CD following surgery.
