Research progress in monkeypox virus and blood transfusion safety
10.3760/cma.j.cn112866-20241229-00189
- VernacularTitle:猴痘病毒与输血安全研究进展
- Author:
Xiangjuan HUANG
1
;
Yan ZHANG
;
Xiangyan HUANG
Author Information
1. 山东医学高等专科学校，济南 250002
- Publication Type:Journal Article
- Keywords:
Monkeypox virus;
Detection techniques;
Transfusion transmission risk;
Transfusion safety
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(3):388-392
- CountryChina
- Language:Chinese
-
Abstract:
Monkeypox virus (MPXV) is a double stranded DNA virus that can be transmitted through animal-human or human-human routes. The experimental method for detecting MPXV infection include virus isolation and culture, electron microscopic observation, antigen and/or antibody detection, and molecular biologic testing. Among them, polymerase chain reaction is the preferred detection method for screening MPXV in blood donors. Blood may not be the main route of interpersonal transmission of MPXV, but there is a potential risk of transfusion transmission of MPXV during the viremia stage, and multiple factors affect the possibility of transfusion transmission of MPXV. Pathogen reduction techniques are a proactive strategy to reduce the risk of transfusion transmission of MPXV in virus-endemic areas. The development of molecular method for rapid and accurate diagnosis of MPXV and the study of the infectious dose required for transfusion transmission of MPXV are essential for the development of effective strategies to maintain transfusion safety.
