Research progress of gut bacterial-derived extracellular vesicles in inflammatory bowel disease
10.3760/cma.j.cn101480-20240710-00075
- VernacularTitle:肠道细菌来源的细胞外囊泡在炎症性肠病中的研究进展
- Author:
Zhimin MA
1
;
Chen WANG
;
Xiaolan ZHANG
Author Information
1. 河北医科大学第二医院消化内科，石家庄 050000
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Extracellular vesicle;
Gut microbiota
- From:
Chinese Journal of Inflammatory Bowel Diseases
2025;09(3):245-249
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of gut. The pathogenesis of IBD is complex, and gut microbiota plays an important role. Gut bacterial-derived extracellular vesicles (GBEV), as a large number of bacterial derivatives and an important mediator between host and microbiome, plays an important role in the pathogenesis of IBD. In recent years, many studies have found that GBEV involves in the occurrence and development of IBD, and has a broad prospect in the diagnosis and treatment of IBD. This article reviews the production and classification of GBEV, especially the mechanism of GBEV in maintaining epithelial barrier, regulating immunity and regulating dysbacteriosis in IBD, in order to provide new ideas for the research of GBEV in IBD.
