Progress and application of single-cell sequencing technology in inflammatory bowel disease

VernacularTitle:单细胞测序技术在炎症性肠病中的应用
Author: Xiu SHI ¹ ; Yu FU ¹
Author Information

1. 华中科技大学同济医学院附属协和医院消化内科，武汉　430022
Publication Type:Journal Article
Keywords: Inflammatory bowel disease; Single-cell sequencing; Heterogeneity; Precision medicine
From: Chinese Journal of Inflammatory Bowel Diseases 2025;09(3):238-244
CountryChina
Language:Chinese
Abstract: Inflammatory bowel disease (IBD) is characterized by intestinal immune dysregulation, and the mechanisms underlying the cellular and molecular dynamics in the intestinal microenvironment remain unelucidated. The collaborative function of gastrointestinal epithelial, stromal and immune cells and the interaction between cells and intestinal microbiota play important roles in maintaining intestinal immune homeostasis. Currently, single-cell sequencing technology is developing rapidly, and its application in IBD continues to deepen. This article reviews single-cell analysis studies of IBD in recent years, with the aim of providing a basis for understanding the pathogenesis of IBD and promoting precision medicine.