Role of sulfation in the pathogenesis of inflammatory bowel disease
10.3760/cma.j.cn101480-20250312-00040
- VernacularTitle:磺酸化在炎症性肠病致病机制中的作用
- Author:
Ying NIU
1
;
Chen GAO
;
Dongxue QI
;
Xiancao HUANG
;
Pengfei XU
Author Information
1. 武汉大学药学院药物科学系，武汉 430071
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Sulfation;
Pathogenesis;
Intestinal barrier
- From:
Chinese Journal of Inflammatory Bowel Diseases
2025;09(3):187-192
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a refractory disease characterized by chronic intestinal inflammation. Its typical pathological characteristics are the destruction of intestinal mucosal barrier and the imbalance of immune microenvironment. In severe cases, it can cause intestinal fibrosis and functional failure. Sulfation, a critical post-translational modification, plays an essential role in regulating intestinal homeostasis. Abnormal sulfation metabolism in the intestine of IBD patients can lead to the impairment of intestinal barrier function, immune system disorders and changes in the composition of microbiota. Consequently, targeting the sulfation pathway may be a novel therapeutic strategy for IBD. By supplementing exogenous sulfation substrates, regulating the activity of related key enzymes involved in sulfation or remodeling the microbiota, the level of intestinal sulfation can be effectively restored, thereby repairing the intestinal barrier function and inhibit the inflammatory response. This article systematically summarizes the pathogenic mechanisms of sulfation in IBD, providing a theoretical foundation for developing precision therapeutic strategies targeting the intestinal microenvironment.
