Analysis of the epidemiological characteristics of adenovirus enteritis in hospitalized children in China from 2016 to 2021
10.3760/cma.j.cn112866-20241017-00152-1
- VernacularTitle:2016—2021年我国住院儿童腺病毒肠炎的流行病学特征分析
- Author:
Jiao TIAN
1
;
Yuxin SHAO
;
Xinyu WANG
;
Qi LI
;
Guoshuang FENG
;
Yueping ZENG
;
Ran WANG
;
Zhengde XIE
Author Information
1. 国家儿童医学中心 首都医科大学附属北京儿童医院 北京市儿科研究所感染与病毒研究室 中国医学科学院儿童危重感染诊治创新单元 国家呼吸系统疾病临床医学研究中心 儿科重大疾病研究教育部重点实验室，北京 100045
- Publication Type:Journal Article
- Keywords:
Adenovirus gastroenteritis;
Epidemiology;
Hospitalization;
Children
- From:
Chinese Journal of Experimental and Clinical Virology
2024;38(6):687-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This report analyzed the epidemiological characteristics of adenovirus enteritis in hospitalized children based on data from a nationwide multicenter study.Methods:We analyzed patient admission records of children hospitalized for adenoviral enteritis from the FUTang Update medical Records (FUTURE) database. Data were collected from 22 tertiary pediatric hospitals between January 2016 and December 2021. The study focused on identifying epidemiological trends and assessing the disease burden.Results:A total of 1 638 children were hospitalized for adenovirus gastroenteritis, accounting for 0.03% (1 638/5 465 249) of all hospitalizations in this age group and 2.88% (1 638/56 859) of diarrhea-related hospitalizations. The male-to-female ratio was 1.47∶1, with more males affected across all age groups, years, and regions. The majority of hospitalizations (77.41%) occurred among children aged 7 months to 2 years, who also represented the highest proportion (0.070%) of hospitalizations within their age group. Additionally, the number of hospitalizations increased annually from 2016 to 2021, with a noticeable rise in admissions during the summer and autumn months (July-October). Two-thirds of the patients had no significant extraintestinal comorbidities, while approximately one-fifth developed respiratory comorbidities such as pneumonia or acute bronchitis. The median length of hospital stay was 5 days (IQR 3.75-6), and the median hospitalization cost was 4 582.56 RMB (IQR 3 261.52-6 256.87).Conclusions:This study highlights adenovirus gastroenteritis as a significant cause of diarrhea-related hospitalizations in children in China, particularly among those aged 7 months to 2 years. Hospitalization rates were notably higher in males, with a peak in admissions during July to October. Most children experienced no extraintestinal comorbidities.
