Cytological origin of intimal hyperplasia in autologous arteriovenous fistula
10.3760/cma.j.cn441217-20240219-00223
- VernacularTitle:自体动静脉内瘘内膜增生的细胞学来源
- Author:
Yafei BAI
1
;
Ruman CHEN
1
;
Mingjiao PAN
1
;
Mingzhi XU
1
;
Na AN
1
;
Chunli WANG
1
;
Hong LI
1
Author Information
1. 海南省人民医院（海南医学院附属海南医院）血液净化中心，海口 570311
- Publication Type:Journal Article
- Keywords:
Renal dialysis;
Arteriovenous fistula;
Tunica interna;
Cell proliferation;
Hyperplasia
- From:
Chinese Journal of Nephrology
2025;41(5):389-393
- CountryChina
- Language:Chinese
-
Abstract:
Autogenous arteriovenous fistula (AVF), compared to other vascular access routes, offers the advantages of stable blood flow, fewer complications, and a longer service life, making it the primary type of vascular access and the first choice for hemodialysis patients. The failure rate of AVF maturation is as high as 20% to 60%, primarily due to intimal hyperplasia following AVF surgery. Currently, the origin, function, and differentiation status of neointimal cells are not well understood, and most knowledge about neointimal cells was inferred from arterial neointima in non-AVF systems. Understanding the source of neointimal cells in AVF is crucial for experimental design and effectively providing strategies to reduce intimal hyperplasia. This article reviews the situation of venous intimal hyperplasia in patients with stage 5 chronic kidney disease, the relationship between changes in venous vessel wall and neointimal cells after AVF surgery, and the effects of outer membrane fibroblasts, local smooth muscle cells, and circulating bone marrow progenitor cells on AVF intimal hyperplasia. It is hoped that this will provide a reference for the treatment of intimal hyperplasia and experimental research.
