The nomogram and prognostic risk staging of chromophobe renal cell carcinoma were constructed based on comprehensive pathological information
10.3969/j.issn.1673-9701.2025.25.013
- VernacularTitle:基于全面病理信息构建肾嫌色细胞癌预后列线图及风险分期
- Author:
Zhengdao YANG
1
;
Tielin WU
;
Jifang ZHANG
Author Information
1. 宁波大学附属李惠利医院普外科,浙江宁波 315000
- Publication Type:Journal Article
- Keywords:
Chromophobe renal cell carcinoma;
Nomogram;
Predictive model;
TNM staging
- From:
China Modern Doctor
2025;63(25):54-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic predictors of patients with chromophobe renal cell carcinoma(ChRCC),and to construct a nomogram model and prognostic risk staging.Methods The data of this study were derived from the Surveillance,Epidemiology,and End Results(SEER)database.Cox regression analysis was used to determine the independent prognostic factors,and a nomogram model was constructed to predict the survival period of patients with ChRCC.The discrimination and accuracy of the model were evaluated using the consistency index and calibration curve.Prognostic risk staging was established and compared with the TNM staging system.Results A total of 6382 patients with ChRCC were included.They were randomly divided into training group(n=4467)and validation group(n=1915)in a 7:3 ratio.The results of the Cox regression analysis showed that age,gender,race,place of residence,lymph node metastasis,bone metastasis,lung metastasis,tumor breaking through the renal capsule,major vein invasion,pathological appearance of sarcomatous features,and surgical method were all independent influencing factors for the prognosis of ChRCC(P＜0.05).The C-index of this nomogram prognostic model was significantly higher than that of the TNM staging system(0.790 vs.0.617).The same trend was also observed in the validation group.The K-M survival curve based on the prognostic risk staging by the nomogram showed that there was a significant difference among the populations in each stage(P＜0.001),and the discrimination was superior to the TNM staging of renal cancer.Conclusion The prognostic nomogram model for ChRCC patients constructed based on comprehensive pathological factors can achieve high accuracy and stability.The prognostic risk staging established by this model can serve as a practical supplementary tool for evaluating the prognosis of ChRCC patients in clinical practice.
