Causal relationship between blood lipids and osteoporosis:Based on a Mendelian randomization study
10.3969/j.issn.1673-9701.2025.25.012
- VernacularTitle:血脂与骨质疏松症的因果关系:基于孟德尔随机化研究
- Author:
Junyi LI
1
;
Kanghua ZHONG
Author Information
1. 广州中医药大学研究生院,广东 广州 510006
- Publication Type:Journal Article
- Keywords:
Lipids;
Osteoporosis;
Mendelian randomization;
Causality
- From:
China Modern Doctor
2025;63(25):50-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on Mendelian randomization(MR),the causal relationship between blood lipids and osteoporosis(OP)was explored,with the aim of providing a reference for the prevention and treatment of OP.Methods Data on the relevant lipid profiles and OP associated single nucleotide polymorphisms were extracted from publicly available genome-wide association study(GWAS)databases.Subsequent secondary analysis of the GWAS data was conducted,treating different lipid profiles as exposures and OP as the outcome.The analysis was performed using inverse variance weighted(IVW),MR-Egger,weighted median,and other methods,with Cochran's Q test employed to assess heterogeneity in the MR results.The reliability of the causal relationship was further assessed using the MR-Egger intercept test and the MR-PRESSO test.Results The univariable MR analysis demonstrated significant causal associations between OP and several lipid parameters:total cholesterol(P=0.007,OR=1.003,95％CI:1.001-1.005),triglycerides(P=0.013,OR=0.997,95％CI:0.995-0.999),low density lipoprotein cholesterol(P=0.029,OR=1.002,95％CI:1.000-1.002),and apolipoprotein B(P=0.014,OR=1.003,95％CI:1.001-1.003).There was no significant causal relationship between the other blood lipid types and OP.The multivariable MR analysis revealed no significant causal associations between the eight lipid parameters and OP,while the reverse univariable MR analysis similarly demonstrated no causal relationships between OP and the eight lipid measures.Conclusion Total cholesterol,low density lipoprotein cholesterol and apolipoprotein B are risk factors for OP and will increase the risk of OP onset.Triglycerides have a negative causal correlation with OP,suggesting that it has a potential protective effect.
