Application of cell block technique in the diagnosis of papillary thyroid carcinoma
10.3969/j.issn.1673-9701.2025.25.010
- VernacularTitle:细胞蜡块技术在甲状腺乳头状癌诊断中的应用
- Author:
Yanpei WANG
1
;
Haiyan CHEN
;
Junhong LI
;
Yifei LIU
;
Wenyu ZHAO
;
Liang HE
;
Yanfang ZHANG
Author Information
1. 郑州大学附属洛阳中心医院内分泌科,河南洛阳 471099
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
Ultrasound-guided fine needle aspiration biopsy;
Cell smear;
Cell block;
BRAFV600E gene detection;
Diagnosis
- From:
China Modern Doctor
2025;63(25):41-44,60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application of cell block(CB)technology in the diagnosis of papillary thyroid carcinoma(PTC).Methods A total of 86 patients with thyroid nodules who were treated at Luoyang Central Hospital Affiliated to Zhengzhou University from February 2023 to December 2024 were retrospectively selected.Before the operation,all patients underwent ultrasound-guided fine needle aspiration biopsy.After the biopsy,the specimens were respectively subjected to cell smear(CS)and CB pathological examinations.Using postoperative pathology as the gold standard,the clinical application value of CS,CB,BRAFV600E gene detection,and combined detection in the preoperative diagnosis of PTC was evaluated.Results A total of 86 patients were included.Among them,42 cases were diagnosed as PTC by postoperative pathology,and 44 cases were benign lesions.The sensitivity(73.81％),specificity(97.73％),positive predictive value(96.88％),negative predictive value(79.63％),and accuracy(86.05％)of CB in the preoperative diagnosis of PTC were significantly higher than those of CS.The Kappa consistency test results showed that the consistency between CB pathological results and postoperative pathological results was better than that of CS.Receiver operating characteristic curve analysis indicated that the area under the curve(AUC)of CB was significantly higher than that of CS(0.858 vs.0.743,Z=2.391,P=0.017).Furthermore,the combination of CB and BRAFV600E gene detection further improved preoperative diagnostic performance,with a consistency with postoperative pathological results(Kappa=0.837)superior to other examination methods,and an AUC(0.918)significantly higher than other examination methods.Conclusion CB has significant clinical application value in the preoperative diagnosis of PTC,with diagnostic performance significantly superior to CS.Further combination with BRAFV600E gene detection can significantly improve preoperative diagnostic accuracy.
