Clinical application value of shear wave dispersion imaging in evaluating segmental mucosal healing in patients with Crohn's disease
10.3760/cma.j.cn101480-20240307-00034
- VernacularTitle:剪切波频散成像在评估克罗恩病节段性黏膜愈合的临床应用价值
- Author:
Zhuohua LIANG
1
;
Wenjie CHENG
;
Si QIN
;
Guangjian LIU
Author Information
1. 中山大学附属第六医院超声科 广州 510655
- Publication Type:Journal Article
- Keywords:
Crohn's disease;
Mucosal healing;
Shear wave elastography;
Shear wave dispersion slope
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(5):371-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the application value of shear wave dispersion (SWD) imaging in evaluating segmental mucosal healing in patients with Crohn's disease (CD) .Methods:Eighty-nine patients who were comprehensively confirmed to have CD by clinical, endoscopic, and pathologic evidence were prospectively evaluated. The affected intestinal segments were divided into mucosal healing and non-mucosal healing groups based on simple endoscopic score for Crohn's disease. The value of shear wave dispersion slope (SWDS) in evaluating mucosal healing was determined using receiver operating characteristic (ROC) curve analysis, and compared with shear wave elastic modulus (SWEM), shear wave velocity (SWS), bowel wall thickness (BWT), bowel wall stratification (BWS), and Limberg classification.Results:There were 24 cases of mucosal healing and 65 cases of non-mucosal healing in the 89 CD patients in this study. There were significant differences in SWDS, SWEM, SWS, BWT, BWS, and Limberg classification between the mucosal healing and non-mucosal healing groups (all P < 0.05). The ROC curve showed that the AUC of SWDS in diagnosing mucosal healing was better than that of BWT, SWEM, and SWS (all P < 0.05), but with no significant differences compared to BWS ( P = 0.28) and Limberg grading ( P = 0.13). At the same time, SWDS combined with BWT could significantly improve the diagnostic performance of BWT for mucosal healing ( P=0.0003) . Conclusion:SWD imaging can serve as an effective complement to routine ultrasound in assessing segmental mucosal healing in patients with CD, and has clinical application value.
