The application of fecal calprotectin in the diagnosis of infectious diarrhea in children
10.3969/j.issn.1673-9701.2025.25.001
- VernacularTitle:粪便钙卫蛋白在儿童感染性腹泻诊断中的应用
- Author:
Jie WANG
1
;
Xinfeng ZHAO
;
Huiting TAO
;
Shiyong ZHAO
;
Xianyao LIN
Author Information
1. 杭州市儿童医院检验科,浙江 杭州 310014
- Publication Type:Journal Article
- Keywords:
Fecal calprotectin;
Children;
Infectious diarrhea;
Viral;
Bacterial
- From:
China Modern Doctor
2025;63(25):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic significance of fecal calprotectin(FC)in infectious diarrhea in children.Methods A total of 190 children with infectious diarrhea who were hospitalized in Hangzhou Children's Hospital from August 2021 to July 2024 were selected and divided into bacterial group(115 cases)and viral group(75 cases)according to type of pathogen.48 children who underwent health examination in the hospital during the same period were included in control group.The FC,white blood cell count(WBC),C-reactive protein(CRP),and procalcitonin(PCT)of three groups of children were detected.The diagnostic efficacy of FC,WBC,CRP and PCT for bacterial infectious diarrhea was evaluated by using the receiver operating characteristic(ROC)curve.Results The proportions of fever and hematochezia,the highest body temperature,frequency of defecation,and fecal white blood cells in bacterial group were significantly higher than those in viral group,while the proportion of vomiting was significantly lower than that in viral group(P＜0.05).There were statistically significant differences in levels of WBC,CRP,PCT and FC among three groups of children(P＜0.05),and the levels were all in the order of bacterial group＞viral group＞control group.The results of ROC curve showed that area under the curve(AUC)of FC for diagnosing bacterial diarrhea was 0.941,with a sensitivity of 87.0％and a specificity of 85.4％.The AUC,sensitivity and specificity of the diagnosis by FC combined with CRP were 0.987,93.0％and 97.9％respectively.Correlation analysis indicated that FC was positively correlated with WBC and CRP levels(r-0.221,0.159,P＜0.05).Conclusion FC is helpful in differentiating bacterial diarrhea from viral diarrhea,and the combined detection of FC and CRP can effectively improve the effectiveness of differential diagnosis and reduce the misdiagnosis rate.
