Prospects of gut microbiome in the precision medicine of inflammatory bowel disease
10.3760/cma.j.cn101480-20240715-00082
- VernacularTitle:肠道微生物组学在炎症性肠病精准医学应用的前景
- Author:
Caiguang LIU
1
;
Ren MAO
1
Author Information
1. 中山大学附属第一医院消化内科，广州 510080
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Gut microbiome;
Precision Medicine
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(5):343-349
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory intestinal disease that can affect the entire digestive tract, mainly including ulcerative colitis and Crohn's disease. Currently, the etiology and pathogenesis of IBD have not been fully elucidated and may be related to genetic susceptibility, environmental factors, abnormal immune response, impaired intestinal barrier, and imbalance of gut microbiota. With the advancement of high-throughput sequencing technology, the application of gut microbiome in precision medicine for IBD has become more extensive and in-depth. Utilizing the gut microbiome can enable earlier detection of disease signs, accurate prediction of disease development trends, and real-time monitoring of its progression, providing new possibilities for individualized treatment of IBD. This article reviews and summarizes the existing evidence of gut microbiome in the precise diagnosis and typing of IBD, monitoring disease progression, and predicting therapeutic effects, and also looks forward to the prospects of microbiome applications in precision medicine.
