Roles study of colonic lamina propria macrophages in ulcerative colitis
10.3760/cma.j.cn101480-20231030-00051
- VernacularTitle:结肠固有层巨噬细胞在溃疡性结肠炎中的作用研究
- Author:
Xin ZHAO
1
;
Yuan JIANG
;
Wenli DAN
;
Huiyuan ZHANG
;
Juan LI
;
Jinghong SHI
;
Lihua CHEN
Author Information
1. 陕西中医药大学医学技术学院，咸阳 712046
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Macrophages;
Colonic lamina propria;
Cytokine
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(4):309-313
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the intestine closely associated with immune dysfunction. Colonic lamina propria macrophages are the most abundant population of macrophages in the intestinal mucosa, capable of effectively maintaining and regulating the stability of the intestinal environment. The inflammatory responses mediated by these macrophages play a significant role in the occurrence and development of UC. This article provides a comprehensive review of the roles and mechanisms of two different subtypes of colonic lamina propria macrophages in UC, aiming to provide new insights for the clinical treatment of UC.
