Research progress of nanozymes in the treatment of acute kidney injury
10.3760/cma.j.cn441217-20241113-01125
- VernacularTitle:纳米酶在急性肾损伤治疗中的研究进展
- Author:
Xinyu SUN
1
;
Wenfeng GUO
;
Tingting WANG
;
Huirong LI
;
Lu ZHOU
;
Hongbao LIU
Author Information
1. 西安医学院研究生院，西安 710021
- Publication Type:Journal Article
- Keywords:
Acute kidney injury;
Reactive oxygen species;
Nanoparticles;
Nanozymes
- From:
Chinese Journal of Nephrology
2025;41(5):403-408
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury (AKI), a life-threatening clinical syndrome, lacks effective therapeutic interventions beyond supportive care such as hemodialysis and kidney transplantation. Pathologically, excessive reactive oxygen species -mediated oxidative stress is recognized as a pivotal contributor to AKI progression, positioning reactive oxygen species scavenging as a critical therapeutic target. Emerging nanozymes, nanomaterials with enzyme-mimetic activities, have shown promise in addressing AKI by targeting renal oxidative stress. The article mainly reviewed the content of classification of nanozymes, research findings on nanozymes in treating AKI along with discussions on their mechanisms of action, as well as the current challenges and existing issues in nanozymes-based AKI therapy, to provide enhanced research perspectives for advancing nanozyme applications in the prevention and treatment of AKI.
