Biological function of soluble α-Klotho and its protective mechanism against renal injury
10.3760/cma.j.cn441217-20240104-00104
- VernacularTitle:可溶性α-Klotho的生物学功能及肾脏保护作用的可能机制
- Author:
Yan ZHANG
1
;
Hui LIAO
;
Zhicheng TAN
;
Rongshan LI
Author Information
1. 山西省人民医院（山西医科大学第五临床医学院）和平院区肾内科，太原 030000
- Publication Type:Journal Article
- Keywords:
Kidney diseases;
Molecular biology;
Cytoprotection;
Soluble α-Klotho;
Kidney mechanism
- From:
Chinese Journal of Nephrology
2025;41(1):63-69
- CountryChina
- Language:Chinese
-
Abstract:
The α-Klotho protein is an anti-aging protein encoded by the Klotho gene and mainly exists in the renal tubules in the form of type 1 membrane protein (membrane-boundform). The extracellular domain of the membrane-bound α-Klotho protein can be cleaved and secreted into the circulation, which is called soluble α-Klotho. Soluble α-Klotho is the main form that can be detected in the body fluid. This paper mainly reviews the biological functions of soluble α-Klotho in the kidney and its possible molecular biological mechanisms, and also summarizes the role of soluble α-Klotho in various kidney diseases and the effects of α-Klotho on the other organs.
