A case of lupus nephritis complicated with thrombotic microangiopathy
- VernacularTitle:重度狼疮肾炎合并血栓性微血管病1例
- Author:
Yuqiu LIU
1
;
Chun JIANG
1
;
Fengmei WANG
1
;
Yan YANG
1
;
Bin WANG
1
;
Xiaoliang ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Lupus nephritis; Thrombotic microangiopathy; Eculizumab
- From: Chinese Journal of Nephrology 2025;41(1):58-62
- CountryChina
- Language:Chinese
- Abstract: This paper reported a case of severe lupus nephritis in an adolescent with progressive hemolytic anemia, thrombocytopenia, and multiple organs involvement, in which renal damage was characterized by sustained elevation of serum creatinine and oliguria. Accurate diagnosis of lupus nephritis complicated with thrombotic microangiopathy was achieved through genetic testing and molecular technology. The use of double filtration plasmapheresis, blocking B-cell targets and complement activation targets, and supplementing frozen plasma provided more accurate, safe and effective treatment options for patients, which significantly improved prognosis.
