Multivariate analysis of cognitive dysfunction in maintenance hemodialysis patients
10.3760/cma.j.cn441217-20240410-00420
- VernacularTitle:维持性血液透析患者认知功能障碍的多因素分析
- Author:
Yafei BAI
1
;
Ruman CHEN
1
;
Mingzhi XU
1
;
Na AN
1
;
Chunli WANG
1
;
Xin ZENG
1
;
Jifeng LI
1
;
Qian WEI
1
;
Hong LI
1
Author Information
1. 海南省人民医院（海南医科大学附属海南医院）血液净化中心，海口 570311
- Publication Type:Journal Article
- Keywords:
Renal insufficiency, chronic;
Renal dialysis;
Risk factors;
Cognitive dysfunction
- From:
Chinese Journal of Nephrology
2025;41(1):49-53
- CountryChina
- Language:Chinese
-
Abstract:
This study was a single-center cross-sectional investigation aimed at identifying risk factors for cognitive dysfunction in patients undergoing maintenance hemodialysis (MHD), with the goal of providing a basis for improving patient prognosis. Patients receiving MHD in the Blood Purification Center of Hainan Provincial People's Hospital from June 1 to June 30, 2023, were enrolled. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), and potential risk factors for cognitive impairment were analyzed by using Logistic regression. A total of 278 patients were included, 69 patients (24.8%) of whom had cognitive impairment. Multivariate Logistic regression analysis indicated that the history of cerebrovascular disease ( OR=3.109, 95% CI 1.310-7.378, P=0.010), old age ( OR=1.077, 95% CI 1.040-1.115, P<0.001), low dialysis frequency ( OR=0.270, 95% CI 0.120-0.606, P=0.001), low academic qualification (using college/university as the control group: primary school group OR=26.960, 95% CI 7.519-96.673, P<0.001; Junior high school/technical secondary school group OR=4.264, 95% CI 1.330-13.650, P=0.015; High school group OR=9.554, 95% CI 2.861-31.904, P<0.001), high β2-microglobulin ( OR=1.609, 95% CI 1.044-2.480, P=0.031) and high C-reactive protein/albumin ( OR=2.672, 95% CI 1.226-5.826, P=0.013) were independent risk factors for cognitive impairment in MHD patients.
