Relationship between preoperative use of anti-tumor necrosis factor-α and postoperative infectious complications in Crohn′s disease
10.3760/cma.j.cn101480-20240206-00019
- VernacularTitle:克罗恩病术前使用抗肿瘤坏死因子-α单克隆抗体与术后感染性并发症的相关性研究
- Author:
Kangling DU
1
;
Shixian WANG
;
Zhenya SUN
;
Ming DUAN
;
Lei CAO
;
Yi LI
;
Weiming ZHU
Author Information
1. 南京医科大学附属金陵临床医学院（东部战区总医院）普通外科 炎症性肠病治疗中心，南京 210002
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Tumor necrosis factor-α;
Infectious complications;
Risk factors
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(3):211-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of preoperative anti-tumor necrosis factor (anti-TNF) -α monoclonal antibody therapy on postoperative infectious complications in patients with Crohn′s disease (CD) after intestinal resection with primary anastomosis.Methods:The clinical data of CD patients who underwent intestinal resection with primary anastomosis at Jinling Hospital from January 2017 to December 2021 were retrospectively analyzed. Propensity score matching was used to match patients who did not receive or received anti-TNF treatment within 12 weeks before surgery at a ratio of 1∶2. The relationship between preoperative anti-TNF treatment and postoperative infectious complications was analyzed, and the related risk factors of postoperative infectious complications were analyzed by logistic regression analysis.Results:A total of 501 patients with CD who underwent resection and primary anastomosis were collected. After propensity score matching, 135 patients with CD were included in the analysis, 45 in the treatment group and 90 in the control group. There were no significant differences in the incidence of overall postoperative complications (24.4% vs. 25.6%, P = 0.889) and infectious complications (13.3% vs. 14.4%, P = 0.861) between the two groups. Previous history of intestinal resection due to CD and surgical site of colon were independent risk factors for infectious complications within 30 days after surgery. Conclusion:Previous history of intestinal resection of CD and colon surgery are associated with infectious complications after intestinal resection with primary anastomosis.
