Analysis of medication patterns and mechanisms of the"phlegm-stasis co-treatment"in the treatment of stroke
10.3969/j.issn.1673-9701.2025.25.015
- VernacularTitle:"痰瘀同治"法治疗中风的用药规律及机制探讨
- Author:
Xiuzhi LI
1
;
Jiafu XU
;
Wenli XIONG
;
Jieling LU
;
Baoquan WEN
;
Yuqin HE
Author Information
1. 广州中医药大学研究生学院,广东 广州 510000
- Publication Type:Journal Article
- Keywords:
Intertwined phlegm and blood stasis pattern;
Stroke;
Data mining;
Network pharmacology
- From:
China Modern Doctor
2025;63(25):66-71,78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the medication patterns of the"phlegm-stasis co-treatment"in the treatment of stroke and the regulatory mechanisms of its key components.Methods The relevant literature on the treatment of stroke with intertwined phlegm and blood stasis pattern by traditional Chinese medicine in CNKI,Wanfang Data Knowledge Service Platform and VIP was collected.Excel 2019 and SPSS Modeler 18.0 were applied to statistically analyze the nature,taste,meridian tropism and frequency of the drugs included in the prescriptions.The Apriori algorithm was used to perform association rule analysis and cluster analysis.The potential mechanism of action of the core drug pair was explored by using the network pharmacology method.Results A total of 69 prescriptions involving 161 herbs with 902 cumulative frequency uses were included.The four natures were mainly warm,neutral and cold,the five flavors were mainly bitter,sweet and pungent.and channel tropism were mainly liver meridian and spleen meridian.The analysis of association rules indicates that there was a strong correlation among chuanxiong,Taoren,Dannanxing,Dilong,Honghua,Shichangpu and Fuling.The main active components of the drug combination were quercetin,gallic acid,baicalein and hederagenin.They can regulate signaling pathways such as hypoxia-inducible factor-1,advanced glycation end product/advanced glycation end product receptor,nuclear factor κB,and mixed lineage kinase 3 by acting on genes such as STAT3,SRC,JUN,TP53,and MAPK1.Conclusion The core drugs of"phlegm-stasis co-treatment"method can act on multiple targets and pathways through components such as quercetin,gallic acid,baicalein and hederagenin,thereby exerting a therapeutic effect on stroke.
