Research progress of ETS-1 in inflammatory bowel disease and colitis-associated colorectal cancer
10.3760/cma.j.cn101480-20231118-00065
- VernacularTitle:ETS-1在炎症性肠病及结肠炎相关性结直肠癌中的研究进展
- Author:
Xufan SUN
1
;
Guiyuan JIN
;
Cuimei MA
;
Yan WANG
;
Huihui ZHOU
;
Guangxi ZHOU
Author Information
1. 济宁医学院临床医学院，济宁 272067
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Colitis-associated colorectal cancer;
ETS proto-oncogene 1;
Intestinal epithelial cell barrier;
Immunomodulation
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(2):164-168
- CountryChina
- Language:Chinese
-
Abstract:
ETS proto-oncogene 1 (ETS-1) is a member of ETS transcription factor family and plays essential roles in tumorigenesis and inflammation. ETS-1 promotes the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) by inducing inflammation, destroying the intestinal epithelial cell barrier, and increasing the invasiveness of cancer cells. This article reviews the research progress of ETS-1 in IBD and CAC in order to investigate the pathogenesis and underlying treatment targets of IBD and CAC.
