Research advances in exosomes and miRNAs in the diagnosis of severe mental illnesses
10.3760/cma.j.cn112150-20250311-00194
- VernacularTitle:外泌体及miRNA在严重精神障碍诊断中的研究进展
- Author:
Wendi ZHANG
1
;
Xiaoyu WANG
1
;
Shujuan PAN
1
Author Information
1. 北京回龙观医院医学检验中心 北京大学回龙观临床医学院，北京 100096
- Publication Type:Journal Article
- Keywords:
Exosomes;
microRNA;
Severe mental illnesses;
Central nervous system
- From:
Chinese Journal of Preventive Medicine
2025;59(11):1978-1988
- CountryChina
- Language:Chinese
-
Abstract:
The clinical diagnosis of serious mental illnesses (SMI) has long been constrained by the limitations of traditional symptomatic criteria and the absence of objective biological markers. Exosomes, serving as natural nanocarriers capable of crossing the blood-brain barrier, along with the miRNAs they carry, offer novel molecular markers for the precise diagnosis of SMI. This article summarizes recent research advances on exosomes in schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorder, exploring the potential mechanisms by which they participate in the regulation of neuroinflammation and synaptic dysfunction through the delivery of miRNA molecules. Although the specific origins and monitoring of exosomes require further investigation, their value in assisting the diagnosis of psychiatric disorders is increasingly being recognized, holding promise for providing more objective references for clinical practice in the future.
