Cell-mediated glomerulonephritis without immune complexes deposition: a case report
10.3760/cma.j.cn441217-20240603-00601
- VernacularTitle:细胞介导不伴免疫复合物沉积的肾小球肾炎1例
- Author:
Yingxin XIE
1
;
Junyan FANG
;
Yan LI
;
Shaojun LIU
;
Yingli LIU
Author Information
1. 上海交通大学医学院附属第九人民医院肾内科，上海 200011
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis;
Acute kidney injury;
T-lymphocytes;
Macrophages;
Endocapillary hypercellularity
- From:
Chinese Journal of Nephrology
2025;41(6):445-448
- CountryChina
- Language:Chinese
-
Abstract:
The paper reports a case of endocapillary proliferative glomerulonephritis without immune complex deposition, presenting with acute kidney injury and proteinuria. Renal pathology was characterized by predominant T cells and CD68 + macrophages infiltration in glomerular capillaries without immunocomplex deposits. After glucocorticoid therapy, the patient's condition has improved and reached complete remission. This type of renal pathology is extremely rare. Through literature review, it is considered that they may be caused by abnormal immune cells such as T cells and/or macrophages-mediated immune responses. It should be taken seriously in clinical practice, and its underlying causes and pathogenesis need further research.
