Application of Klotho in the integrated diagnosis and treatment of acute kidney injury
10.3760/cma.j.cn441217-20240214-00219
- VernacularTitle:Klotho在急性肾损伤一体化诊治中的应用
- Author:
Qifeng LIU
1
;
Yuanmao TU
;
Zhen CHENG
;
Weixin HU
Author Information
1. 江苏大学附属昆山医院肾脏内科，苏州 215300
- Publication Type:Journal Article
- Keywords:
Acute kidney injury;
Diagnosis;
Treatment;
Prognosis;
Klotho
- From:
Chinese Journal of Nephrology
2025;41(1):70-76
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury (AKI) is one of the common critical illnesses characterized by a higher incidence, poor prognosis and limited effective therapeutics in clinical practice. Early diagnosis, etiologic differentiation and prognostic evaluation are crucial for improving outcomes and key components of integrated AKI management. However, the lack of ideal markers and intervention targets poses significant challenges in these aspects. Klotho, a protein predominantly synthesizes and secretes by renal tubular epithelial cells, has been shown to exert various protective effects on the kidney. Recent evidence suggests that abnormal Klotho levels are implicated in the pathogenesis and development of AKI, and hold promise for application in early diagnosis, etiologic recognition, and prognostic evaluation of AKI. Additionally, administration of exogenous Klotho protein or upregulation of endogenous Klotho expression has demonstrated preventive and therapeutic efficacy against AKI caused by a variety of etiologies. This paper reviewed the alterations in Klotho levels during AKI and evaluated its potential role in enhancing the integrated diagnosis and treatment of AKI.
