Ferroptosis and its role in kidney tubular injury in diabetic kidney disease
10.3760/cma.j.cn441217-20240314-00315
- VernacularTitle:铁死亡及其在糖尿病肾脏疾病肾小管损伤中的作用
- Author:
Ziyi LI
1
;
Jianqin WANG
Author Information
1. 兰州大学第二临床医学院肾内科，兰州 730030
- Publication Type:Journal Article
- Keywords:
Ferroptosis;
Diabetic nephropathies;
Kidney tubules;
Lipid peroxidation;
Iron metabolism
- From:
Chinese Journal of Nephrology
2025;41(2):144-153
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a type of programmed cell death characterised by iron-dependent accumulation of lipid reactive oxygen species, which is closely related to intracellular metabolism of amino acids, lipids, and iron, and regulation of ferroptosis can intervene and treat certain diseases. Diabetic kidney disease (DKD) is a chronic microvascular complication of diabetes.Although the exact pathogenesis of DKD is not clear, the results of the existing studies have proved that ferroptosis participates in the development of diabetic kidney injury, and plays an important role in kidney tubular injury in particular, and the inhibition of ferroptosis may be one of the directions for the treatment of DKD. In recent years, researchers have conducted a lot of studies on ferroptosis through animal models of DKD, but the specific pathogenesis and therapeutic effects regarding ferroptosis have not been fully revealed. This article introduces ferroptosis and its connection with apoptosis, autophagy and other forms of cell death, as well as the main mechanisms regulating the development of ferroptosis through systematic Xc-GSH-GPX4 axis, NADPH-FSP1-CoQ10 axis, GCH1-BH4- phospholipid axis and various regulatory factors, and provides an overview of its role in kidney tubular injury of DKD. Through the review of these contents, the possibility of ferroptosis as a therapeutic target for DKD is discussed, in order to provide reference for the basic research and clinical treatment of DKD.
