Ulcerative colitis with primary sclerosing cholangitis: six cases report and literature review
10.3760/cma.j.cn101480-20230202-00012
- VernacularTitle:溃疡性结肠炎合并原发性硬化性胆管炎的临床特点并文献复习
- Author:
Chenfei TAN
1
;
Yating YANG
;
Lingya YAO
;
Qian CAO
Author Information
1. 浙江大学医学院附属邵逸夫医院消化内科，杭州 310016
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Primary sclerosing cholangitis;
Extraintestinal manifestations;
Clinical characteristics;
Prognosis
- From:
Chinese Journal of Inflammatory Bowel Diseases
2023;07(3):267-271
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical characteristics of ulcerative colitis (UC) with primary sclerosing cholangitis (PSC) .Methods:The clinical characteristics, diagnosis and treatment of 6 UC patients with PSC admitted to Sir Run Run Shaw Hospital affiliated to Zhejiang University School of Medicine from May 2017 to May 2022 were analyzed retrospectively. Meanwhile "ulcerative colitis", "primary sclerosing colangitis" were used as retrieval words to search associated literatures from CNKI, Wanfang Data, and PubMed databases as of August 2022. Relevant literatures were reviewed and summarized.Results:There were 6 UC patients complicated with PSC, included 4 males and 2 females. Four UC cases were diagnosed before PSC and other 2 cases were diagnosed simultaneously. Six cases were all extensive colonic type (E3), 2 patients were rectal sparing, and 4 patients had backwash ileitis. Five patients had elevated alkaline phosphatase (AKP) levels. All the patients received oral treatment with ursodeoxycholic acid (UDCA). Two patients with concurrent cholangiocarcinoma died within one year of follow-up. A total of 75 relevant literatures were retrieved.Conclusions:Patients with UC complicated with PSC are often diagnosed with UC before PSC, and PSC is often discovered due to abnormal liver function. The main clinical manifestations include jaundice, abdominal pain and diarrhea, and some may be accompanied by symptoms such as fever, vomiting, and fatigue. There are clinical characteristics such as elevated AKP, pancolitis, rectal sparing, and backwash ileitis. UC complicated with PSC is more likely to develop cholangiocarcinoma.
