One case of IgA vasculitis nephritis in children with positive antineutrophil cytoplasmic antibodies
10.3760/cma.j.cn441217-20240527-00537
- VernacularTitle:伴抗中性粒细胞胞质抗体阳性的儿童IgA血管炎肾炎1例
- Author:
Fangping TANG
1
;
Wei CHEN
;
Kaiwei LI
;
Jian CHEN
Author Information
1. 武汉科技大学医学部医学院，武汉 430070
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis, IgA;
Vasculitis;
Antibodies, antineutrophil cytoplasmic;
Children;
Treatment
- From:
Chinese Journal of Nephrology
2024;40(12):965-967
- CountryChina
- Language:Chinese
-
Abstract:
IgA vasculitis (IgAV) is more common in children with vasculitis, while antineutrophilcytoplasmicantibodies (ANCA) associated vasculitis (AAV) in children is relatively rare. We report a case of IgA vasculitis nephritis with ANCA positive in a child. The clinical manifestations of the child were consistent with rapidly progressive nephritis syndrome, and the serum MPO-ANCA was strongly positive. Pathologically, crescentic glomerulonephritis was mainly presented, accompanied by a large amount of IgA deposition in the mesangial area. After treatment with glucocorticoids, rituximab and symptomatic treatment, the child's condition was relieved. This report aims to improve the understanding of the diagnosis and treatment of renal damage caused by vasculitis in children.
