Research progress on the effects of circadian rhythm disturbance on β-cell function
10.3760/cma.j.cn311282-20240911-00409
- VernacularTitle:昼夜节律紊乱对β细胞功能影响的研究进展
- Author:
Zhe WANG
1
;
Limin WANG
;
Ling LI
;
Huijuan YUAN
Author Information
1. 郑州大学人民医院（河南省人民医院）内分泌与代谢科，郑州 450003
- Publication Type:Journal Article
- Keywords:
Circadian rhythm;
β cells;
Diabetes mellitus
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(6):515-517
- CountryChina
- Language:Chinese
-
Abstract:
Circadian rhythm synchronize internal biological functions with environmental light-dark cycles. Impaired pancreatic β-cell function is a critical mechanism in the development and progression of type 2 diabetes. Emerging evidence suggests that circadian rhythm disturbances—caused by factors such as shift work, sleep deprivation, and gene mutations—are closely associated with β-cell dysfunction. This review summarizes recent research advances on the relationship between circadian rhythm disturbance and impaired β-cell function, and explores the potential underlying mechanisms.
