A case report and literature review of pituitary stalk interruption syndrome complicated by liver cirrhosis and hepatopulmonary syndrome
10.3760/cma.j.cn311282-20240730-00333
- VernacularTitle:一例垂体柄阻断综合征伴肝硬化及肝肺综合征报道并文献复习
- Author:
Yali ZHU
1
;
Ting BAI
1
;
Sheli LI
1
;
Wei LI
1
;
Xia LI
1
Author Information
1. 延安大学附属医院内分泌代谢科，延安 716000
- Publication Type:Journal Article
- Keywords:
Pituitary stalk interruption syndrome;
Hypopituitarism;
Liver cirrhosis;
Hepatopulmonary syndrome;
Recombinant human growth hormone therapy
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(9):769-772
- CountryChina
- Language:Chinese
-
Abstract:
Pituitary stalk interruption syndrome(PSIS) typically manifests initially as short stature due to growth hormone deficiency(GHD). Untreated chronic GHD may induce metabolic disturbances, leading to non-alcoholic fatty liver disease with rapid progression to liver cirrhosis. Liver cirrhosis can subsequently cause hepatopulmonary syndrome, resulting in hypoxemia and dyspnea. This article reports a case of a young male presenting with short stature, dyspnea, liver cirrhosis, and hepatopulmonary syndrome, ultimately diagnosed with PSIS. Following recombinant human growth hormone(rhGH) and other hormonal replacement therapies, the patient exhibited improvement in hepatic steatosis and fibrosis, with alleviation of dyspnea. Through analysis of this case, we provide clinical insights for diagnosing and managing cirrhosis and hepatopulmonary syndrome in such patients, highlighting that early diagnosis and timely initiation of rhGH replacement therapy can improve prognosis and quality of life.
