Role of non-immune cell components in the creeping fat involved in Crohn′s disease development
10.3760/cma.j.cn101480-20221209-00199
- VernacularTitle:爬行脂肪中的非免疫细胞成分在克罗恩病发生发展中的作用
- Author:
Yongheng WANG
1
;
Weigang SHU
;
Chuanding LI
;
Zhuoma DEJI
;
Xiaolei WANG
Author Information
1. 同济大学附属第十人民医院消化内科，上海 200072
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Creeping fat;
Non-immune cells;
Inflammation
- From:
Chinese Journal of Inflammatory Bowel Diseases
2023;07(4):351-354
- CountryChina
- Language:Chinese
-
Abstract:
The thickened and hypertrophic mesenteric fat that surrounds the inflamed intestine over 50% in Crohn′s disease (CD) is commonly defined as creeping fat. Most previous studies have focused on the mechanism of interaction between immune cells and translocated bacteria in it. However, the massive non-immune cells, including adipose-derived stem cells, adipocytes, endothelial cells and fibroblasts etc. in the mesenteric fat tissue have often been neglected. With the increasing evidence on non-immune cells in the pathogenesis of CD, their involvement in immune homeostasis and regulation of inflammationis gaining new insights. This review highlights the latest research progress on the impact of non-immune cell components in creeping fat, improving the pathogenesis of CD and explores new strategies based on mesenteric therapy.
