The role of adipocyte-specific calsyntenin 3β in obesity: From molecular mechanisms to clinical associations
10.3760/cma.j.cn311282-20241205-00577
- VernacularTitle:脂肪细胞特异性蛋白Calsyntenin 3β在肥胖中的作用：从分子机制到临床关联
- Author:
Ningning BAI
1
;
Ying YANG
Author Information
1. 深圳大学第一附属医院内分泌科，深圳市代谢性疾病临床医学研究中心，深圳 518035
- Publication Type:Journal Article
- Keywords:
Calsyntenin 3β;
Adipocyte;
Obesity;
Lipid metabolism;
Genetic variation
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(8):704-707
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is characterized by excessive accumulation of adipose tissue or ectopic lipid deposition, and is closely linked to insulin resistance and related metabolic disorders. Calsyntenin 3β(CLSTN3β) is a recently discovered protein that is specifically expressed in adipocytes. This article summarizes its role in obesity, from molecular mechanisms to clinical associations. Mechanistic studies have shown that mouse CLSTN3β, as an endoplasmic reticulum membrane protein, promotes lipid droplet multilocularity and lipid utilization in thermogenic adipocytes, while also facilitating lipid droplet maturation and lipid storage in white adipocytes. Clinical studies have revealed that the transcriptional profile of the human CLSTN3B gene in white adipose tissue tightly associated with obesity, and key metabolic traits, and that its genetic variation may play an important role. These findings will provide new insights and directions for intervention strategies aimed at improving obesity-associated metabolic disorders.
