Application prospect of rapamycin in inflammatory bowel disease
10.3760/cma.j.cn101480-20220815-00127
- VernacularTitle:雷帕霉素在炎症性肠病中的应用前景
- Author:
Bingjie XIANG
1
;
Qi ZHANG
;
Min ZHANG
;
Min ZHI
Author Information
1. 中山大学附属第六医院消化内科，广州 510655
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Rapamycin;
Mammalian target of rapamycin;
Autophage
- From:
Chinese Journal of Inflammatory Bowel Diseases
2023;07(3):297-300
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, it has been found that mammalian target of rapamycin (mTOR) is related to the pathogenesis of inflammatory bowel disease (IBD). Rapamycin plays an important role in inflammatory response, cell proliferation, metabolism, apoptosis and autophagy by inhibiting mTOR. To better understand the application prospects of rapamycin in IBD, this paper reviews the mechanism of action of rapamycin, clinic application and the current application status of rapamycin in IBD.
