Ten-year incidence of reproductive system malignancies among overweight and obese women with different metabolic phenotypes aged 40 years and above in Guiyang City
10.3760/cma.j.cn311282-20250329-00166
- VernacularTitle:贵阳市40岁及以上不同代谢表型超重与肥胖女性10年生殖系统恶性肿瘤发病率的调查研究
- Author:
Yalan WANG
1
;
Nianchun PENG
;
Miao ZHANG
;
Ying HU
;
Rui WANG
;
Juan HE
;
Qiao ZHANG
;
Lixin SHI
Author Information
1. 贵州医科大学附属医院内分泌代谢病科，贵阳 550004
- Publication Type:Journal Article
- Keywords:
Overweight;
Obesity;
Metabolic syndrome;
Females;
Reproductive system;
Malignant tumors
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(8):621-626
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the 10-year incidence of reproductive system malignancies and their associated risk factors among overweight and obese women with different metabolic phenotypes aged 40 years and older in Guiyang City.Methods:A total of 6 444 female residents in Yunyan District, Guiyang City were included from the 2011 " Epidemiological Study on the Risk of Malignancy in Chinese Patients with Type 2 Diabetes Mellitus(REACTION)". Based on body mass index(BMI) and the presence or absence of metabolic syndrome(MetS), participants were categorized into four groups: metabolically healthy normal weight(MHNW, n=2 373), metabolically unhealthy normal weight(MUNW, n=1 098), metabolically healthy overweight/obese(MHO, n=2 229), and metabolically unhealthy overweight/obese(MUO, n=744). Baseline data were collected, and participants were followed up for 10 years to document the incidence of female reproductive system malignancies, including breast cancer, ovarian cancer, cervical cancer, and endometrial cancer. Logistic regression models were used to evaluate the association between metabolic phenotype and the 10-year risk of developing reproductive system malignancies. Results:Over a mean follow-up period of (9.89±0.77) years, the overall incidence of reproductive system malignancies was 1.15%(74/6, 444). Baseline characteristics such as age, BMI, high-density lipoprotein-cholesterol(HDL-C), and triglycerides(TG) differed significantly among the groups( P<0.05). The cumulative incidence of reproductive system malignancies in each group was: MHNW 0.93%(22/2 373), MUNW 0.73%(8/1 098), MHO 1.57%(35/2 229), and MUO 1.21%(9/744). There were no statistically significant differences in incidence across the four groups( P>0.05). However, multivariable logistic regression analysis revealed that, compared with the MHNW group, the adjusted HR (95% CI) were: MUNW 0.787(0.349-1.774, P>0.05), MHO 4.835(1.708-13.688, P<0.05), and MUO 3.719(1.144-12.089, P<0.05). Conclusion:Overweight and obesity are significant risk factors for reproductive system malignancies in women aged 40 and above. The presence of metabolic abnormalities in overweight or obese women further increases the risk of developing such malignancies.
