Effect of hypertriglyceridemia on adverse pregnancy outcomes in late pregnancy with normal thyroid function
10.3760/cma.j.cn311282-20250113-00023
- VernacularTitle:高三酰甘油血症对甲状腺功能正常的妊娠晚期孕妇不良妊娠结局的影响
- Author:
Tao WANG
1
;
Chengwen SONG
;
Huafang WEI
;
Yiming HOU
;
Jiayang TANG
;
Qiaojun ZHENG
;
Ling YUE
Author Information
1. 武汉科技大学医学部医学院，武汉 430065
- Publication Type:Journal Article
- Keywords:
Triglyceride;
Thyroid-stimulating hormone receptor;
Thyroid function;
Adverse pregnancy outcomes;
Gestational diabetes mellitus
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(7):546-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate risk factors for adverse pregnancy outcomes(APO) in women with hypertriglyceridemia(HTG) during late pregnancy despite normal thyroid function, focusing on thyroid-stimulating hormone receptor(TSHR) levels.Methods:A total of 242 pregnant women with normal thyroid function who delivered in General Hospital of Central Theater Command from October 2023 to June 2024 were divided into HTG( n=111) and non-HTG groups( n=131). Clinical data, lipid profiles, thyroid function, TSHR levels, and APO were compared, and the influencing factors of APO were analyzed. Results:Compared with non-HTG group, APO, adverse maternal outcomes, and gestational diabetes mellitus(GDM) were significantly more frequent in the HTG group( P<0.05). The HTG group also had higher triglyceride(TG), fasting plasma glucose(FPG), triglyceride glucose index(TyG), triglyceride/high density lipoprotein cholesterol(TG/HDL-C), thyroid stimulating hormone(TSH) and TSHR, with lower free triiodothyronine (FT 3)( P<0.05). TSHR was an independent risk factor for APO, maternal adverse outcomes, and GDM in all pregnant women( OR=1.112, 95% CI 1.007-1.229; OR=1.126, 95% CI 1.020-1.243; OR=1.133, 95% CI 1.025-1.253) and was also an independent risk factor for APO in the HTG group( OR=1.165, 95% CI 1.005-1.351). Conclusion:Pregnant women with normal thyroid function and HTG in late pregnancy are more likely to have APO, manifested as maternal adverse outcomes and GDM. TSHR is an independent risk factor for APO.
