Cytokine-driven pathogenesis and targeted therapeutics in thyroid eye disease
10.3760/cma.j.cn311282-20250617-00310
- VernacularTitle:从细胞因子视角解析甲状腺眼病的发病机制与靶向治疗策略
- Author:
Yufan SHAO
1
;
Yu YANG
;
Chao LIU
;
Kun WANG
Author Information
1. 南京医科大学附属江宁医院内分泌科，南京 211100
- Publication Type:Journal Article
- Keywords:
Thyroid eye disease;
Cytokines;
Pathogenesis;
Therapeutic targets
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(11):970-975
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid eye disease(TED), also known as thyroid-associated ophthalmopathy(TAO) or Graves' ophthalmopathy(GO), is an organ-specific autoimmune disorder associated with autoimmune thyroid disease and can severely impair vision and quality of life. The pathogenesis of TED is closely linked to dysregulated cytokine networks; however, current therapies yield limited response rates in patients with moderate-to-severe TED. This review synthesizes the mechanisms of action of key cytokines and evaluates the translational potential of emerging targeted therapies, aiming to provide a rationale for overcoming current therapeutic bottlenecks and advancing precision treatment strategies.
