Evaluation value of PICaSSO histological remission index in ulcerative colitis
10.3760/cma.j.cn101480-20220818-00129
- VernacularTitle:PICaSSO组织学缓解指数在溃疡性结肠炎疾病评估中的价值
- Author:
Xin JIN
1
;
Weixun ZHOU
;
Gechong RUAN
;
Yan YOU
;
Lixin JIN
;
Ji LI
;
Jiaming QIAN
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院消化内科，北京 100730
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Paddington international virtual chromoendoscopy score;
PICaSSO histologic remission index;
Mayo endoscopic score;
Ulcerative colitis
- From:
Chinese Journal of Inflammatory Bowel Diseases
2023;07(3):244-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical values of PICaSSO histological remission index (PHRI) in evaluation of ulcerative colitis (UC) .Methods:A cross-sectional study was conducted. Clinical data of UC patients diagnosed in the Department of Gastroenterology of Peking Union Medical College Hospital from June 2018 to October 2019 were collected, including demography characteristics, Montreal classification, serological indicatiors, Mayo score and Mayo endoscopic score (MES), ulcerative colitis endoscopic index of severity (UCEIS), Robarts histopathology index (RHI) and PHRI. Mayo score was used to evaluate the clinical activity of the disease. MES = 0 or UCEIS ≤1 point was defined as endoscopic remission (ER), and RHI ≤3 points or PHRI<1 point as histological remission (HR). Spearman correlation analysis was used to evaluate the correlations of PHRI with serological indicators, endoscopic scores, and RHI. Kappa test was used to analyze the consistency between scores. Results:A total of 60 UC patients (31 men, 29 women; mean age, 40.5±13.7 years) were enrolled. The lesion located in the rectum (E1) in 11 patients, left colon (E2) in 14 and extensive colon (E3) in 35. According to the Mayo score, clinical remission occurred in 20 patients, mild activity in 20, moderate activity in 12 and severe activity in 8. A total of 15 patients with PHRI<1 point were assigned to PHRI-HR group, while 45 patients with PHRI≥1 point were assigned to non-HR group. Spearman correlation analysis showed that there was a negative correlation between PHRI and serum albumin level ( r s = -0.327, P = 0.011) ; there were strong positive correlations of PHRI with MES and UCEIS scores ( r s = 0.698, 0.735, both P<0.001) and there was an extremely strong positive correlation of PHRI with RHI ( r s = 0.868, P<0.001). The difference in serum albumin levels between the PHRI-HR group and the non-HR group was statistically significant ( Z = -2.364, P = 0.018). Kappa consistency test showed that the results of MES-ER and PHRI-HR were moderately consistent ( κ = 0.535, P<0.001), and the specificity and accuracy of PHRI-HR judged by MES-ER were 91.1% and 83.3%, respectively. The results of UCEIS-ER and PHRI-HR were also moderately consistent ( κ = 0.542, P<0.001), and the specificity and accuracy of PHRI-HR judged by UCEIS-ER were 90.5% and 81.7%, respectively. The results of RHI-HR and PHRI-HR were strongly consistent ( κ = 0.644, P<0.001), and the specificity and accuracy of PHRI-HR judged by RHI-HR were 73.3% and 86.7%, respectively. Conclusion:PHRI is strongly correlated with RHI and endoscopic scores and may be a potential optimal histopathological score in evaluation of UC disease activities.
