Correlation between serum bilirubin and disease activity in Crohn′s disease
10.3760/cma.j.cn101480-20221013-00168
- VernacularTitle:血清胆红素与克罗恩病疾病活动度的相关性研究
- Author:
Shiqi LIU
1
;
Yanfang CHEN
;
Lu CHEN
;
Qingxia WANG
;
Yan WANG
;
Xiaoli HUANG
;
Hong CHEN
Author Information
1. 东南大学医学院，南京 210009
- Publication Type:Journal Article
- Keywords:
Crohn′s Disease;
Serum bilirubin;
Crohn′s disease activity index;
Simple endoscopic score for Crohn′s disease
- From:
Chinese Journal of Inflammatory Bowel Diseases
2023;07(3):261-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship of serum levels of total bilirubin (Tbil), indirect bilirubin (Ibil), direct bilirubin (Dbil) with disease symptom activity, and endoscopic activity in patients with Crohn′s disease (CD) .Methods:The demographic characteristics and relevant clinical data of patients with CD and matched healthy control groups from January 2018 to June 2022 were retrospectively collected, the level of serum bilirubin between CD patients and control groups were compared, and the relationship between serum bilirubin level and CD activity was analyzed.Results:A total of 196 patients with CD and 196 healthy controls were included in this study. The serum Tbil, Ibil and Dbil levels of CD patients in the active group were 7.2 (5.4, 9.7) μmol/L, 4.6 (3.4, 6.6) μmol/L and 2.5 (1.7, 3.6) μmol/L, which were lower than those in the control group 11.5 (8.6, 15.0) μmol/L, 7.2 (5.2, 10.0) μmol/L and 4.0 (3.1, 5.3) μmol/L, and in the remission group 11.8 (8.5, 14.6) μmol/L, 8.2 (5.1, 9.5) μmol/L and 4.0 (2.8, 5.2) μmol/L, all the differences were statistically significant ( P all<0.001). In patients with CD, serum Tbil, Ibil and Dbil levels were significantly different between the remission group and the mild, moderate and severe activity group ( P all<0.001), and the bilirubin levels were lower in patients with high disease activity. In simple endoscopic score for CD (SES-CD), there were significant differences of serum Tbil, Ibil and Dbil levels in patients with CD scores <3, 3 to 6, 7 to 15 and ≥16 ( P all<0.005), and bilirubin levels were lower in patients with high endoscopic activity. Ordered Logistic regression showed that CD patients with low serum levels of Tbil, Ibil and Dbil had a higher risk of disease activity compared to the highest quartile bilirubin levels, both in CD activity index and SES-CD. Conclusion:Serum bilirubin level is closely related to CD disease activity, and patients with low serum bilirubin level are more likely to develop into disease activity.
