Effect of peripheral white blood cell levels in the first and second trimesters on adverse pregnancy outcomes
10.3760/cma.j.cn311282-20250509-00251
- VernacularTitle:妊娠早期和中期外周血白细胞水平对妊娠不良结局的影响
- Author:
Yu ZHANG
1
;
Chuanwei LIU
;
Xuesong LI
;
Yujuan FAN
;
Jialin YANG
;
Yuping SONG
;
Zhiqiang LU
Author Information
1. 复旦大学附属中山医院内分泌科，上海 200032
- Publication Type:Journal Article
- Keywords:
Peripheral white blood cell counts;
Gestational diabetes mellitus;
Gestational hypertension;
Preeclampsia
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(11):940-944
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of peripheral white blood cell(WBC) count on adverse pregnancy outcomes.Methods:A retrospective analysis was conducted on pregnant women who delivered at Minhang Hospital affiliated with Fudan University between January 2013 and June 2020. Demographic data, WBC counts, and diagnostic information on gestational diabetes mellitus(GDM), gestational hypertension, and preeclampsia/eclampsia were extracted from electronic medical records. Logistic regression models were used to evaluate the association between WBC counts in the first(WBC-1) and second trimesters(WBC-2) and metabolically related pregnancy outcomes.Results:A total of 24 143 pregnant women were included, with a mean age of(29.1±4.9) years and a mean pre-pregnancy body mass index(BMI) of(21.1±2.8) kg/m 2. The mean WBC counts in the first and second trimesters were 8.1×10 9/L and 8.9×10 9/L, respectively. The incidence rates of GDM, gestational hypertension, and preeclampsia/eclampsia were 5.6%, 4.8%, and 1.8%, respectively. After adjusting for relevant confounders, a core standard deviation( s) increase in WBC-1 was associated with a 6%, 18%, and 14% increased risk of GDM, gestational hypertension, and preeclampsia/eclampsia, respectively( P<0.001). Similarly, a one s increase in WBC-2 was associated with a 10% increased risk for all three adverse outcomes( P<0.001). Conclusion:Elevated peripheral WBC levels in the first and second trimesters are independently associated with increased risk of adverse pregnancy outcomes, independent of traditional risk factors.
