A 10-year follow-up study on the predictive value of ECG PR interval for coronary heart disease events in patients with type 2 diabetes mellitus
10.3760/cma.j.cn311282-20240907-00402
- VernacularTitle:2型糖尿病患者PR间期对冠心病事件10年发生风险的预测价值研究
- Author:
Jing DAI
1
;
Song ZHANG
;
Nianchun PENG
;
Miao ZHANG
;
Ying HU
;
Juan HE
;
Qiao ZHANG
;
Lixin SHI
Author Information
1. 贵州医科大学附属医院内分泌代谢科，贵阳 550004
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Coronary atherosclerotic heart disease;
PR interval;
Predictive value
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(5):372-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the early predictive value of ECG PR interval for the risk of coronary heart disease(CHD) in patients with T2DM.Methods:A total of 7 886 participants from Guiyang who enrolled in the REACTION study between May and August 2011 were included. Baseline data were collected, and participants were followed for 10 years to monitor the occurrence of CHD. Logistic regression was used to identify risk factors for CHD, and a Cox proportional hazards model was employed to assess the predictive value of the PR interval for CHD incidence. Results:Over 10 years of follow-up, the overall incidence of CHD was 4.22%(245/5 812). The incidence was significantly higher in the T2DM group(7.57%, 96/1 268) than in the non-T2DM(3.28%, 149/4 544), and the shortened PR group(3.19%, 36/1 130; all P<0.05). Multiple logistic regression analysis identified both T2DM and prolonged PR interval as significant risk factors for CHD, with HR(95% CI) of 1.98(1.64-2.42) and 1.07(1.04-1.10), respectively(both P<0.01). The Cox proportional hazards model further revealed that the risk of CHD was significantly higher in the prolonged PR group than in the normal PR group, with an HR of 2.82(95% CI 2.34-3.12, P<0.01). Subgroup analysis showed that the risk of CHD was elevated in the non-T2DM with prolonged PR group, T2DM with normal PR group, and T2DM with prolonged PR group compared to the non-T2DM with normal PR group, with HRs(95% CI) of 1.43(1.14-1.82), 2.16(1.78-2.56), and 5.24(3.12-7.94), respectively. A significant interaction was observed between T2DM status and PR prolongation in predicting CHD risk(all P<0.01). Conclusions:Both T2DM and prolonged PR interval are independent risk factors for 10-year CHD incidence. Moreover, an interaction exists between T2DM and prolonged PR interval in predicting CHD risk. The PR interval may serve as an early predictor of CHD risk in patients with T2DM.
