Research progress on G protein-coupled receptors in bone metabolism-related diseases
10.3760/cma.j.cn311282-20241011-00460
- VernacularTitle:G蛋白偶联受体在骨代谢相关疾病中的研究进展
- Author:
Fan LI
1
;
Fanhua WANG
1
;
Meiling SU
1
;
Jian LUO
1
Author Information
1. 同济大学附属养志康复医院（上海阳光康复中心）骨与关节康复中心，上海 201619
- Publication Type:Journal Article
- Keywords:
G protein-coupled receptors;
Bone metabolism-related diseases;
Regulation mechanism;
Drug targets
- From:
Chinese Journal of Endocrinology and Metabolism
2025;41(10):886-890
- CountryChina
- Language:Chinese
-
Abstract:
G protein-coupled receptors(GPCRs) are ubiquitously expressed in various human tissues and organs, playing a crucial role in regulating nearly all physiological processes. The dysfunction of GPCRs has been directly linked to the onset and progression of a wide range of diseases, including those related to bone metabolism. This review highlights recent findings on the regulatory mechanisms of GPCRs in osteoporosis(2019 to present) and osteoarthritis(2022 to present), along with a discussion of translational research. Additionally, the article provides an outlook on potential directions for future studies in this area.
